AAAS

Across TCGA cell cohorts, AAAS mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AAAS-associated genes across cancer lineages are CABP5, MYL10, and GALR3. Each is linked with AAAS in more than 1 cancer types. Because this analysis shows association rather than direction, both AAAS-to-partner and partner-to-AAAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by AAAS-low versus AAAS-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAAS→partner) and Y-score (partner→AAAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP5 →	+0.011	+3.452	<.001	.004	3	2
BLOOD_Lymphoma	MYL10 →	+0.101	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	GALR3 →	+0.092	+3.938	<.001	.002	3	1
BLOOD_Lymphoma	AKAP4 →	+0.166	+3.169	<.001	.008	3	1
BLOOD_Lymphoma	LCN9 →	+0.012	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	BIRC8 →	+0.002	+3.925	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CABP5 by AAAS expression — BLOOD_Lymphoma

Explore this box plot interactively →