A2ML1

Across TCGA patient cohorts, A2ML1 mutation is significantly associated with the RNA expression of many other genes, with 6,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible A2ML1-associated genes across cancer lineages are EXO1, MTHFD2, and GSTM5. Each is linked with A2ML1 in more than 4 cancer types. Because this analysis shows association rather than direction, both A2ML1-to-partner and partner-to-A2ML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXO1 grouped by A2ML1-low versus A2ML1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A2ML1→partner) and Y-score (partner→A2ML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXO1 →	+0.446	+1.651	.004	.001	3	5
UCEC	MTHFD2 →	+0.511	+1.716	.001	.001	3	5
LUAD	GSTM5 →	-0.405	-2.274	.009	.006	3	5
UCEC	BUB3 →	+0.409	+1.727	<.001	.002	3	4
LUAD	CDC25A →	+0.662	+3.356	.002	.004	3	4
STAD	ZNF367 →	+0.963	+3.207	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,299 associations by consensus.

EXO1 by A2ML1 expression — UCEC

Explore this box plot interactively →