A2ML1

Across TCGA pan-cancer cohorts, A2ML1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of A2ML1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where A2ML1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types A2ML1 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

LUSC, HNSC, and BLCA are the cancer types where A2ML1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in A2ML1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	+4.924	<.001	7	view →
HNSC	All	III,IV	−1.907	.013	6	view →
BLCA	Male	III,IV	+3.557	.004	5	view →
THCA	Female	II,III,IV	−0.127	<.001	5	view →
BRCA	Female	All	+0.517	.001	4	view →
LUAD	Male	All	+0.160	.008	4	view →
UCEC	All	All	+0.742	.018	2	view →
READ	Male	All	+0.330	.009	2	view →
COAD	Female	IV	+0.095	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

A2ML1–LUSC

Open the LUSC breakdown →