A2ML1

Across TCGA cell cohorts, A2ML1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,565 significant associations in total. BONE shows the largest number of these associations.

The most reproducible A2ML1-associated GO terms across cancer lineages are Positive regulation of fat cell differentiation, Cellular response to indole-3-methanol, and Vitamin E metabolic process. Each is linked with A2ML1 in more than 6 cancer types. Because this analysis shows association rather than direction, both A2ML1-to-partner and partner-to-A2ML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of fat cell differentiation grouped by A2ML1-low versus A2ML1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (A2ML1→partner) and Y-score (partner→A2ML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of fat cell differentiation →	+0.068	+0.575	<.001	.002	3	7
BREAST	Cellular response to indole-3-methanol →	+0.189	+1.286	<.001	.006	3	7
BONE	Vitamin E metabolic process →	-0.322	-0.880	<.001	.001	3	7
LUNG_NSCLC_LUSC	NMDA selective glutamate receptor signaling pathway →	+0.202	+0.288	.005	.001	3	6
LARGE_INTESTINE	Post-transcriptional gene silencing →	+0.048	+0.397	.001	.005	3	6
LUNG_NSCLC_LUSC	Positive regulation of lipase activity →	-0.313	-0.427	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,565 associations by consensus.

Positive regulation of fat cell differentiation by A2ML1 expression — URINARY_TRACT

Explore this box plot interactively →