A2ML1

Across TCGA cell cohorts, A2ML1 mutation is significantly associated with the RNA expression of many other genes, with 457 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible A2ML1-associated genes across cancer lineages are PTCRA, GRIFIN, and FGF23. Each is linked with A2ML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both A2ML1-to-partner and partner-to-A2ML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTCRA grouped by A2ML1-low versus A2ML1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A2ML1→partner) and Y-score (partner→A2ML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTCRA →	+0.176	+3.874	<.001	.006	3	2
OVARY	GRIFIN →	+0.035	+5.196	<.001	.005	3	2
LARGE_INTESTINE	FGF23 →	+0.327	+2.364	.002	.002	3	2
LARGE_INTESTINE	LYG1 →	+0.724	+2.502	.006	.005	3	2
LARGE_INTESTINE	PANK1 →	+1.086	+3.169	<.001	.006	3	2
LARGE_INTESTINE	OXNAD1 →	+0.519	+3.321	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

PTCRA by A2ML1 expression — CNS

Explore this box plot interactively →