A2ML1-AS2

Across TCGA pan-cancer cohorts, A2ML1-AS2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated A2ML1-AS2 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher A2ML1-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated A2ML1-AS2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CESC show a favorable association.

READ, MESO, and PAAD are the cancer types where A2ML1-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.059	0.845	<.001	81	view →
MESO	OS	Tertile	III,IV	0.232	0.593	.002	72	view →
PAAD	DFS	Tertile	All	0.204	0.500	<.001	63	view →
BLCA	OS	Tertile	III,IV	0.773	0.517	.007	60	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	39	view →
COAD	OS	Tertile	IV	0.056	0.659	.002	27	view →
CESC	OS	Tertile	All	0.800	0.552	.023	24	view →
LAML	DFS	Tertile	All	0.758	0.469	.008	18	view →
LUAD	DFS	Tertile	IV	0.320	0.724	.016	18	view →
UCEC	DFS	Tertile	All	0.760	0.850	.034	12	view →
TGCT	DFS	Median	All	0.702	0.892	.003	10	view →
STAD	DFS	Tertile	IV	0.160	0.402	.044	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

A2ML1-AS2–READ (DFS)

Open the READ breakdown →