A2ML1-AS1

Across TCGA pan-cancer cohorts, A2ML1-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated A2ML1-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher A2ML1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated A2ML1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and OV show a favorable association.

BRCA, KIRC, and THCA are the cancer types where A2ML1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.908	0.960	<.001	96	view →
KIRC	DFS	Tertile	All	0.434	0.677	<.001	78	view →
THCA	OS	Tertile	III,IV	0.479	0.809	<.001	48	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	36	view →
STAD	DFS	Quartile	IV	0.095	0.428	.001	18	view →
ACC	OS	Tertile	All	0.275	0.664	.026	18	view →
SARC	OS	Tertile	All	0.489	0.757	.006	18	view →
DLBC	OS	Tertile	All	0.448	0.942	.013	15	view →
OV	OS	Tertile	IV	0.640	0.306	.006	12	view →
LGG	DFS	Tertile	All	0.915	0.795	.010	12	view →
PRAD	DFS	Tertile	All	0.969	0.924	.023	12	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

A2ML1-AS1–BRCA (DFS)

Open the BRCA breakdown →