A1CF

Across TCGA pan-cancer cohorts, A1CF mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of A1CF’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where A1CF mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types A1CF is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where A1CF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in A1CF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	II,III,IV	−0.519	<.001	10	view →
PDAC	Female	II,III,IV	−1.758	<.001	7	view →
COAD	Female	III,IV	−0.237	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

A1CF–CCRCC

Open the CCRCC breakdown →