A1CF

Across TCGA patient cohorts, A1CF mutation is significantly associated with the RNA expression of many other genes, with 4,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible A1CF-associated genes across cancer lineages are PCGF1, EIF1AXP1, and RPL14P3. Each is linked with A1CF in more than 3 cancer types. Because this analysis shows association rather than direction, both A1CF-to-partner and partner-to-A1CF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCGF1 grouped by A1CF-low versus A1CF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A1CF→partner) and Y-score (partner→A1CF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCGF1 →	+0.249	+2.171	.004	.009	3	4
SKCM	EIF1AXP1 →	+0.340	+1.536	.001	.003	3	3
UCEC	RPL14P3 →	+0.321	+2.850	.008	<.001	3	3
UCEC	CISD3 →	+0.446	+3.016	.007	<.001	3	3
UCEC	LAS1L →	+0.315	+3.617	.003	.001	3	3
UCEC	OXSM →	+0.353	+2.864	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,576 associations by consensus.

PCGF1 by A1CF expression — UCEC

Explore this box plot interactively →