A1CF

Across TCGA cell cohorts, A1CF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,966 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible A1CF-associated GO terms across cancer lineages are Renal D-glucose absorption, Fatty acid beta-oxidation, and Equilibrioception. Each is linked with A1CF in more than 5 cancer types. Because this analysis shows association rather than direction, both A1CF-to-partner and partner-to-A1CF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Renal D-glucose absorption grouped by A1CF-low versus A1CF-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (A1CF→partner) and Y-score (partner→A1CF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Renal D-glucose absorption →	+2.046	+3.729	<.001	<.001	3	6
STOMACH	Fatty acid beta-oxidation →	+0.090	+1.960	<.001	<.001	3	6
LARGE_INTESTINE	Equilibrioception →	+1.913	+1.568	<.001	<.001	3	6
BLOOD_Lymphoma	Negative regulation of DNA-templated transcription initiation →	+0.052	+0.012	.002	.004	3	6
BLOOD_Lymphoma	Negative regulation of transcription initiation by RNA polymerase II →	+0.052	+0.012	.002	.004	3	6
LIVER	Primary amino compound biosynthetic process →	+1.462	+3.261	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,966 associations by consensus.

Renal D-glucose absorption by A1CF expression — LIVER

Explore this box plot interactively →