A1CF

Across TCGA cell cohorts, A1CF mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible A1CF-associated genes across cancer lineages are GTSF1L, OR5A2, and ZNF716. Each is linked with A1CF in more than 1 cancer types. Because this analysis shows association rather than direction, both A1CF-to-partner and partner-to-A1CF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTSF1L grouped by A1CF-low versus A1CF-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A1CF→partner) and Y-score (partner→A1CF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GTSF1L →	+0.040	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5A2 →	+0.002	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	ZNF716 →	+0.356	+2.882	.003	.009	3	1
LUNG_NSCLC_LUAD	DAOA →	+0.010	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR51J1 →	+0.184	+3.415	.003	.002	3	1
LUNG_NSCLC_LUAD	OR51M1 →	+0.429	+2.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GTSF1L by A1CF expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →