VSP34_8731

Across CCLE and GDSC cell-line panels, response to VSP34_8731 is significantly associated with the RNA expression of multiple genes, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible VSP34_8731 response-associated genes across cancer lineages are PPP1R15A, BCL6, and JUN, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, VSP34_8731 response versus PPP1R15A RNA expression in OVARY (Pearson r = -0.67).

Rna expression biomarkers of VSP34_8731 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP1R15A →	-1.670	-0.856	.009	.012	3	8
OVARY	BCL6 →	-1.829	-0.614	.007	.003	3	8
OVARY	JUN →	-2.507	-0.839	.031	.041	3	8
LUNG_SCLC	FEM1C →	-0.793	-0.427	<.001	<.001	3	7
LUNG_SCLC	RNF182 →	-1.769	-0.363	.018	.017	3	7
OESOPHAGUS	NR1D2 →	-0.808	-0.566	.017	.026	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSP34_8731 response vs PPP1R15A — OVARY

Explore this scatter interactively →