TTK_3146

Across CCLE and GDSC cell-line panels, response to TTK_3146 is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible TTK_3146 response-associated genes across cancer lineages are DYSF, C2CD3, and LRP1, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, TTK_3146 response grouped by DYSF status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of TTK_3146 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DYSF →	-2.169	-0.294	.029	.031	3	3
BLOOD_Lymphoma	C2CD3 →	-2.807	-0.360	.043	.016	3	2
LUNG_SCLC	LRP1 →	-2.681	-0.447	.048	.014	3	2
LUNG_SCLC	CSMD3 →	-1.459	-0.279	.026	.048	3	2
BLOOD_Lymphoma	ANK1 →	+2.884	+0.311	.026	.032	3	2
OVARY	CSMD1 →	+2.000	+0.248	.041	.032	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTK_3146 response by DYSF status — LUNG_NSCLC_LUAD

Explore this box plot interactively →