THZ-2-102-1

Across CCLE and GDSC cell-line panels, response to THZ-2-102-1 is significantly associated with the shRNA dependency of multiple gene dependencies, with BONE cell lines showing a particularly strong set of associations.

The most reproducible THZ-2-102-1 response-associated gene dependencies across cancer lineages are P4HA1, FZD7, and LRRC70, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, THZ-2-102-1 response versus P4HA1 shRNA dependency in BONE (Pearson r = -0.95).

Shrna dependency biomarkers of THZ-2-102-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	P4HA1 →	-0.280	-2.644	.007	.010	3	7
BREAST	FZD7 →	+0.199	+1.165	<.001	.004	3	7
KIDNEY	LRRC70 →	+0.132	+0.732	.006	.022	3	7
BONE	SERPINA4 →	-0.283	-3.266	.015	.015	3	6
SOFT_TISSUE	MGRN1 →	+0.654	+0.865	<.001	.022	3	6
PANCREAS	FTCD →	-0.220	-1.810	.016	.019	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THZ-2-102-1 response vs P4HA1 — BONE

Explore this scatter interactively →