QL-VIII-58

Across CCLE and GDSC cell-line panels, response to QL-VIII-58 is significantly associated with the total protein of multiple proteins, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible QL-VIII-58 response-associated proteins across cancer lineages are TIGAR, BRCA2, and PRAS40_pT246, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, QL-VIII-58 response versus TIGAR total protein in SKIN (Pearson r = -0.53).

Total protein biomarkers of QL-VIII-58 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TIGAR →	-0.687	-0.663	.019	.037	3	5
PANCREAS	BRCA2 →	-0.402	-0.576	.047	.010	3	5
STOMACH	PRAS40_pT246 →	+0.596	+0.918	.001	.006	3	4
STOMACH	Claudin-7 →	-2.982	-1.099	.022	.006	3	4
CNS	Stathmin →	+0.370	+0.677	.004	<.001	3	4
BLOOD_Leukemia	Src_pY416 →	+1.178	+0.585	.028	.005	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QL-VIII-58 response vs TIGAR — SKIN

Explore this scatter interactively →