PLK_6522

Across CCLE and GDSC cell-line panels, response to PLK_6522 is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible PLK_6522 response-associated gene dependencies across cancer lineages are PPM1G, CTNNBL1, and POLR2M, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PLK_6522 response versus PPM1G shRNA dependency in LUNG_NSCLC_LUSC (Pearson r = -0.76).

Shrna dependency biomarkers of PLK_6522 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPM1G →	-0.340	-0.830	.032	.038	3	9
CNS	CTNNBL1 →	+0.520	+0.910	.011	.005	3	8
LUNG_NSCLC_LUSC	POLR2M →	+0.283	+0.742	.031	.027	2	9
OVARY	NDST2 →	-0.221	-0.878	.023	.008	2	9
KIDNEY	KDR →	-0.212	-0.952	.001	.020	3	7
SKIN	AZIN2 →	-0.245	-0.886	.014	.029	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLK_6522 response vs PPM1G — LUNG_NSCLC_LUSC

Explore this scatter interactively →