Omipalisib

Across CCLE and GDSC cell-line panels, response to Omipalisib is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible Omipalisib response-associated gene dependencies across cancer lineages are TREX1, MAGI3, and CALD1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Omipalisib response versus TREX1 shRNA dependency in BLOOD_Leukemia (Pearson r = 0.70).

Shrna dependency biomarkers of Omipalisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TREX1 →	+0.243	+1.693	.049	<.001	3	8
KIDNEY	MAGI3 →	-0.357	-1.252	.005	<.001	3	7
LUNG_SCLC	CALD1 →	+0.384	+0.686	.017	.035	3	6
LUNG_SCLC	EXOC7 →	+0.150	+1.157	.040	.016	3	6
LUNG_SCLC	C8B →	+0.142	+0.711	.016	.021	3	6
LUNG_SCLC	H3P6 →	-0.278	-1.068	.005	.015	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Omipalisib response vs TREX1 — BLOOD_Leukemia

Explore this scatter interactively →