Nelarabine

Across CCLE and GDSC cell-line panels, response to Nelarabine is significantly associated with the shRNA dependency of multiple gene dependencies, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible Nelarabine response-associated gene dependencies across cancer lineages are GAS6, UFC1, and FTH1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Nelarabine response versus GAS6 shRNA dependency in SOFT_TISSUE (Pearson r = 0.79).

Shrna dependency biomarkers of Nelarabine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAS6 →	+0.370	+0.543	.001	.033	3	7
BREAST	UFC1 →	-0.226	-0.278	.028	.038	3	7
BLOOD_Leukemia	FTH1 →	-0.256	-0.855	.003	.011	3	7
SOFT_TISSUE	TBR1 →	-0.171	-0.332	.012	.027	2	8
PANCREAS	DOCK2 →	-0.134	-0.449	.006	.003	3	7
LARGE_INTESTINE	NOBOX →	+0.236	+0.493	.003	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Nelarabine response vs GAS6 — SOFT_TISSUE

Explore this scatter interactively →