IGFR_3801

Across CCLE and GDSC cell-line panels, response to IGFR_3801 is significantly associated with the shRNA dependency of multiple gene dependencies, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible IGFR_3801 response-associated gene dependencies across cancer lineages are NIFK, STK25, and UTP4, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, IGFR_3801 response versus NIFK shRNA dependency in SKIN (Pearson r = 0.54).

Shrna dependency biomarkers of IGFR_3801 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NIFK →	+0.344	+0.676	.009	.011	3	7
LIVER	STK25 →	+0.153	+0.493	.012	.039	2	8
SOFT_TISSUE	UTP4 →	+0.615	+0.948	<.001	.024	2	8
BONE	PER1 →	+0.375	+1.525	.040	.002	3	7
LUNG_SCLC	ABHD16B →	+0.169	+1.116	.012	.015	3	7
STOMACH	TSG101 →	-0.537	-1.299	.021	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFR_3801 response vs NIFK — SKIN

Explore this scatter interactively →