ICL-SIRT078

Across CCLE and GDSC cell-line panels, response to ICL-SIRT078 is significantly associated with the mutation status of multiple genes, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible ICL-SIRT078 response-associated genes across cancer lineages are PCLO, SYNE1, and TNIK, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, ICL-SIRT078 response grouped by PCLO status in BREAST.

Mutation status biomarkers of ICL-SIRT078 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCLO →	+1.327	+0.410	.033	.019	3	3
LUNG_SCLC	SYNE1 →	-1.874	-0.412	.036	.021	3	2
BREAST	TNIK →	+2.649	+0.565	.046	.015	3	2
OVARY	NOTCH1 →	+1.602	+0.442	.012	.040	3	2
STOMACH	LRP1 →	+1.932	+0.524	.036	.029	3	2
LARGE_INTESTINE	EYS →	+1.263	+0.385	.048	.041	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ICL-SIRT078 response by PCLO status — BREAST

Explore this box plot interactively →