GSK343

Across CCLE and GDSC cell-line panels, response to GSK343 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible GSK343 response-associated genes across cancer lineages are CREBBP, PRDM9, and PKD1, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, GSK343 response grouped by CREBBP status in LARGE_INTESTINE.

Mutation status biomarkers of GSK343 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CREBBP →	+2.932	+0.246	.009	.018	3	3
LUNG_NSCLC_LUSC	PRDM9 →	+2.321	+0.541	.047	.013	3	2
LUNG_NSCLC_LUAD	PKD1 →	+2.914	+0.317	.012	.014	3	2
BLOOD_Lymphoma	BRCA2 →	-2.714	-0.308	.037	.004	3	2
LUNG_NSCLC_LUAD	KMT2D →	-2.719	-0.395	.039	.022	3	2
STOMACH	SACS →	+2.932	+0.352	.009	.014	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK343 response by CREBBP status — LARGE_INTESTINE

Explore this box plot interactively →