GSK269962A

Across CCLE and GDSC cell-line panels, response to GSK269962A is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible GSK269962A response-associated gene dependencies across cancer lineages are PARP4, PRR5-ARHGAP8, and DDX47, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK269962A response versus PARP4 shRNA dependency in BLOOD_Leukemia (Pearson r = 0.53).

Shrna dependency biomarkers of GSK269962A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PARP4 →	+0.246	+1.389	.021	.027	3	4
BLOOD_Leukemia	PRR5-ARHGAP8 →	+0.386	+1.389	.019	.027	3	4
SKIN	DDX47 →	+0.265	+0.415	.004	.015	3	4
BREAST	PAX9 →	-0.151	-0.399	.005	.018	3	4
LUNG_NSCLC_LUAD	EDF1 →	-0.184	-0.614	.017	.020	3	3
LUNG_NSCLC_LUAD	SLC46A2 →	+0.283	+0.586	.020	.046	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK269962A response vs PARP4 — BLOOD_Leukemia

Explore this scatter interactively →