GSK269962A

Across CCLE and GDSC cell-line panels, response to GSK269962A is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible GSK269962A response-associated pathways across cancer lineages are Adenosine catabolic process, Positive regulation of mitotic nuclear division, and Distal tubule development, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, GSK269962A response versus Adenosine catabolic process shRNA pathway dependency in LUNG_NSCLC_LUAD (Pearson r = -0.70).

Shrna pathway dependency biomarkers of GSK269962A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Adenosine catabolic process →	-1.632	-0.667	.005	.023	3	4
BLOOD_Leukemia	Positive regulation of mitotic nuclear division →	-0.373	-1.389	.004	.027	3	3
SKIN	Distal tubule development →	-1.377	-0.612	.012	.009	3	3
SKIN	Regulation of presynaptic cytosolic calcium ion concentration →	-1.566	-0.562	.015	.006	2	4
CNS	Melanosome localization →	+1.649	+0.674	.010	.013	2	4
CNS	Pigment granule localization →	+1.649	+0.674	.010	.013	2	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK269962A response vs Adenosine catabolic process — LUNG_NSCLC_LUAD

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