FY026

Across CCLE and GDSC cell-line panels, response to FY026 is significantly associated with the protein abundance of multiple proteins, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible FY026 response-associated proteins across cancer lineages are COASY, HMGCL, and RRP1B, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, FY026 response versus COASY protein abundance in URINARY_TRACT (Pearson r = -0.34).

Protein abundance biomarkers of FY026 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	COASY →	-0.699	-0.394	.005	.032	3	8
BLOOD_Myeloma	HMGCL →	-1.122	-0.895	.005	.012	3	8
LUNG_SCLC	RRP1B →	+0.695	+0.599	.001	<.001	3	8
URINARY_TRACT	EXOC7 →	-1.141	-0.516	<.001	.001	3	8
BONE	RRP15 →	+0.681	+0.521	.004	.008	3	8
UPPER_AERODIGESTIVE_TRACT	PWWP2A →	+0.984	+0.501	.015	.006	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FY026 response vs COASY — URINARY_TRACT

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