Dacinostat

Across CCLE and GDSC cell-line panels, response to Dacinostat is significantly associated with the shRNA dependency of multiple gene dependencies, with CNS cell lines showing a particularly strong set of associations.

The most reproducible Dacinostat response-associated gene dependencies across cancer lineages are DSTYK, SPIB, and RBBP7, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Dacinostat response versus DSTYK shRNA dependency in CNS (Pearson r = -0.47).

Shrna dependency biomarkers of Dacinostat response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DSTYK →	-0.152	-0.507	.017	.003	3	8
BLOOD_Leukemia	SPIB →	-0.133	-0.449	.003	<.001	3	7
LUNG_SCLC	RBBP7 →	-0.205	-0.643	.012	.029	3	7
UPPER_AERODIGESTIVE_TRACT	BTN2A1 →	-0.220	-0.437	.026	.026	3	7
STOMACH	FZD5 →	-0.277	-0.696	.022	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	CARF →	+0.240	+0.733	.003	.009	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dacinostat response vs DSTYK — CNS

Explore this scatter interactively →