DMOG

Across CCLE and GDSC cell-line panels, response to DMOG is significantly associated with the RNA expression of multiple genes, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible DMOG response-associated genes across cancer lineages are SLC16A7, C2CD2L, and ALDH3B1, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, DMOG response versus SLC16A7 RNA expression in LIVER (Pearson r = 0.45).

Rna expression biomarkers of DMOG response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC16A7 →	+2.047	+0.432	.017	.024	3	9
BREAST	C2CD2L →	-0.812	-0.833	.002	.001	3	8
SOFT_TISSUE	ALDH3B1 →	+2.137	+0.694	.011	.003	3	8
STOMACH	SPRY2 →	-2.275	-0.799	.002	<.001	3	8
OVARY	LRP10 →	-1.151	-0.697	.004	.027	3	7
BLOOD_Myeloma	SKP2 →	+0.941	+0.610	.004	.034	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMOG response vs SLC16A7 — LIVER

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