BDF00022089a

Across CCLE and GDSC cell-line panels, response to BDF00022089a is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible BDF00022089a response-associated genes across cancer lineages are COL22A1, EYS, and MUC5B, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, BDF00022089a response grouped by COL22A1 status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of BDF00022089a response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COL22A1 →	-1.874	-0.317	.023	.004	3	3
OESOPHAGUS	EYS →	+2.754	+0.229	.015	.043	3	2
LUNG_NSCLC_LUAD	MUC5B →	+2.222	+0.369	.001	<.001	3	2
LUNG_NSCLC_LUAD	WNK2 →	+3.169	+0.343	.009	.006	3	2
LARGE_INTESTINE	SPTA1 →	+1.286	+0.251	.016	.026	3	2
LARGE_INTESTINE	DCHS1 →	+1.549	+0.330	.006	.003	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BDF00022089a response by COL22A1 status — LUNG_NSCLC_LUAD

Explore this box plot interactively →