AZD8835

Across CCLE and GDSC cell-line panels, response to AZD8835 is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible AZD8835 response-associated proteins across cancer lineages are RPL4, RPL27, and RPL13A, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD8835 response versus RPL4 protein abundance in LUNG_SCLC (Pearson r = 0.52).

Protein abundance biomarkers of AZD8835 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL4 →	+0.630	+0.558	<.001	<.001	3	9
LUNG_SCLC	RPL27 →	+0.582	+0.513	.001	.002	3	8
STOMACH	RPL13A →	+0.701	+0.845	.043	.007	3	8
CNS	RPL18 →	+0.588	+0.411	.003	<.001	3	8
SOFT_TISSUE	BCL2L1 →	-1.667	-0.686	.022	.018	3	8
OESOPHAGUS	MRPL4 →	+0.609	+0.455	.009	.011	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD8835 response vs RPL4 — LUNG_SCLC

Explore this scatter interactively →