743380

Across CCLE and GDSC cell-line panels, response to 743380 is significantly associated with the RNA expression of multiple genes, with CNS cell lines showing a particularly strong set of associations.

The most reproducible 743380 response-associated genes across cancer lineages are SULT1A1, SLC9A7, and RPGRIP1, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 743380 response versus SULT1A1 RNA expression in CNS (Pearson r = 0.81).

Rna expression biomarkers of 743380 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SULT1A1 →	+4.134	+1.581	<.001	<.001	3	10
BLOOD_Leukemia	SLC9A7 →	-1.623	-0.655	.002	.005	2	10
BONE	RPGRIP1 →	+0.546	+0.952	.017	.013	3	8
BONE	MYBL1 →	-2.604	-1.290	.002	.017	3	8
URINARY_TRACT	TMEM184A →	+2.425	+0.669	.021	.015	3	8
OVARY	C10orf55 →	-0.652	-0.654	.013	.040	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

743380 response vs SULT1A1 — CNS

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