5-Fluorouracil

Across CCLE and GDSC cell-line panels, response to 5-Fluorouracil is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible 5-Fluorouracil response-associated genes across cancer lineages are DNAH2, TP53, and MUC5B, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, 5-Fluorouracil response grouped by DNAH2 status in LUNG_SCLC.

Mutation status biomarkers of 5-Fluorouracil response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNAH2 →	-2.807	-0.680	.040	.002	3	3
BLOOD_Leukemia	TP53 →	-1.157	-0.454	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MUC5B →	+2.169	+0.545	.020	.011	3	3
OVARY	USH2A →	+2.944	+0.740	.007	.002	3	3
OVARY	FAT1 →	+2.722	+0.690	.023	.011	3	3
STOMACH	LRP1 →	+2.584	+0.510	.049	.045	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

5-Fluorouracil response by DNAH2 status — LUNG_SCLC

Explore this box plot interactively →