123829

Across CCLE and GDSC cell-line panels, response to 123829 is significantly associated with the protein abundance of multiple proteins, with CNS cell lines showing a particularly strong set of associations.

The most reproducible 123829 response-associated proteins across cancer lineages are GNL3, FTSJ3, and NIFK, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, 123829 response versus GNL3 protein abundance in CNS (Pearson r = 0.48).

Protein abundance biomarkers of 123829 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GNL3 →	+0.811	+0.817	<.001	.048	3	10
BLOOD_Leukemia	FTSJ3 →	+0.435	+0.832	.009	<.001	3	9
BREAST	NIFK →	+0.561	+0.548	.003	.010	2	10
LARGE_INTESTINE	RPL23A →	+0.886	+1.152	<.001	<.001	3	9
BREAST	WDR36 →	+0.687	+0.782	.003	.005	3	8
STOMACH	EBNA1BP2 →	+0.751	+0.800	.032	.007	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

123829 response vs GNL3 — CNS

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