Malonyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Malonyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCSK, MLYCD, and APRT, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Malonyl-CoA metabolic process activity versus FCSK in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FCSK →	+0.465	+0.067	<.001	<.001	3	9
LUAD	MLYCD →	+0.354	+0.053	<.001	.001	3	8
LUAD	APRT →	+0.508	+0.083	<.001	<.001	3	8
LSCC	GCSH →	+0.575	+0.056	<.001	<.001	3	7
PDAC	SUCLG2 →	+0.318	+0.033	.001	<.001	3	6
PDAC	TACC2_S317 →	+0.695	+0.045	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001293 vs FCSK — LUAD

Explore this scatter interactively →