Malonyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Malonyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT8P13, IFIT1B, and PRKCQ-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Malonyl-CoA metabolic process activity versus KRT8P13 in GBM (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KRT8P13 →	-0.687	-0.410	<.001	.009	3	4
HNSC	IFIT1B →	-0.279	-0.502	.008	<.001	2	5
LUAD	PRKCQ-AS1 →	-0.388	-0.871	.001	<.001	3	4
BRCA	BAK1 →	-0.352	-0.361	.001	.005	3	4
PDAC	FREM3 →	-0.170	-0.698	.002	<.001	3	3
LSCC	AMBP →	-0.205	-0.470	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001293 vs KRT8P13 — GBM

Explore this scatter interactively →