Malonyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Malonyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAB1, MARVELD2, and AGR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECAB1 grouped by Malonyl-CoA metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NECAB1 →	-0.550	-1.045	.005	.007	3	4
LUNG_NSCLC_LUAD	MARVELD2 →	+1.145	+0.941	.001	<.001	3	4
BREAST	AGR2 →	+4.233	+0.863	<.001	.001	3	4
BREAST	CD83 →	-1.423	-0.799	<.001	.008	3	4
BREAST	ARHGAP32 →	+0.951	+0.817	<.001	<.001	3	4
BREAST	POC1B →	+0.779	+0.683	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECAB1 by Malonyl-CoA metabolic process activity — CNS

Explore this box plot interactively →