Malonyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Malonyl-CoA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACLY, TFAM, and PTPMT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACLY grouped by Malonyl-CoA metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ACLY →	+0.318	+0.128	<.001	<.001	3	5
BREAST	TFAM →	+0.224	+0.068	<.001	.002	3	5
BLOOD_Lymphoma	PTPMT1 →	+0.259	+0.099	.009	.005	3	4
LIVER	IL25 →	+0.415	+0.116	<.001	.003	3	4
OVARY	PPP4R1L →	+0.232	+0.139	.002	<.001	3	4
LUNG_SCLC	BPTF →	+0.380	+0.107	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACLY by Malonyl-CoA metabolic process activity — URINARY_TRACT

Explore this box plot interactively →