Malonyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Malonyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACACA, UQCRFS1, and BECN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Malonyl-CoA metabolic process activity versus ACACA in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACACA →	+0.788	+1.209	.003	<.001	3	5
URINARY_TRACT	UQCRFS1 →	+0.985	+1.864	.001	<.001	3	4
OVARY	BECN1 →	+0.793	+1.303	.002	<.001	3	4
OESOPHAGUS	ZNF480 →	+0.885	+1.230	.002	<.001	3	3
URINARY_TRACT	TANK →	+0.938	+1.591	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	CSNK1G2 →	+1.071	+1.274	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001293 vs ACACA — PANCREAS

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