Regulation of caveolin-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of caveolin-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, TLN1, and SPARC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of caveolin-mediated endocytosis activity versus VIM in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM →	-0.294	-0.064	<.001	<.001	3	7
GBM	TLN1 →	-0.285	-0.041	.001	.004	3	6
CCRCC	SPARC →	-0.372	-0.090	<.001	<.001	3	6
PDAC	HOOK2 →	+0.178	+0.064	<.001	<.001	3	6
PDAC	SEC23A →	-0.247	-0.063	<.001	.002	3	5
HNSC	STARD7 →	+0.250	+0.080	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001286 vs VIM — PDAC

Explore this scatter interactively →