Regulation of caveolin-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of caveolin-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC20P1, TFPT, and WDR13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of caveolin-mediated endocytosis activity versus MUC20P1 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MUC20P1 →	+1.181	+0.608	.001	.002	3	3
LUAD	TFPT →	-0.340	-0.455	<.001	.003	3	2
LSCC	WDR13 →	+0.350	+0.649	<.001	.001	3	2
LSCC	MYH14 →	+0.879	+0.890	<.001	<.001	3	2
LSCC	OTX1 →	+0.776	+0.614	<.001	.001	3	2
LSCC	GSTM1 →	+1.769	+0.844	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001286 vs MUC20P1 — LSCC

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