Positive regulation of unsaturated fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTAFR, NKG7, and IFNG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of unsaturated fatty acid biosynthetic process activity versus PTAFR in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PTAFR →	+0.833	+0.217	<.001	<.001	3	6
CCRCC	NKG7 →	+1.002	+0.170	<.001	<.001	3	6
CCRCC	IFNG →	+0.800	+0.144	<.001	<.001	3	6
CCRCC	CD3D →	+0.945	+0.160	<.001	<.001	3	6
COAD	CD2 →	+1.005	+0.242	<.001	<.001	3	6
GBM	CD53 →	+0.865	+0.762	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001280 vs PTAFR — COAD

Explore this scatter interactively →