Regulation of unsaturated fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAMF1, ARHGAP9, and ACAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of unsaturated fatty acid biosynthetic process activity versus SLAMF1 in CCRCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLAMF1 →	+0.616	+0.155	<.001	<.001	3	5
LSCC	ARHGAP9 →	+0.610	+0.359	<.001	<.001	3	5
COAD	ACAP1 →	+0.476	+0.192	.001	<.001	3	5
CCRCC	HLA-F →	+0.616	+0.149	<.001	.005	2	6
CCRCC	TRBV4-2 →	+0.783	+0.120	<.001	<.001	3	5
CCRCC	LINC00426 →	+0.507	+0.138	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001279 vs SLAMF1 — CCRCC

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