Regulation of unsaturated fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJD3, MRPL50, and DENND4B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJD3 grouped by Regulation of unsaturated fatty acid biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GJD3 →	+0.683	+0.750	<.001	.006	3	3
LUNG_NSCLC_LUAD	MRPL50 →	+0.379	+0.766	.002	<.001	3	3
SKIN	DENND4B →	+0.526	+0.705	<.001	.002	3	3
OVARY	RASSF2 →	+0.937	+0.783	.005	.001	3	2
OVARY	COX7B →	+0.665	+0.991	.004	.001	3	2
OVARY	NIPSNAP2 →	+0.411	+0.662	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJD3 by Regulation of unsaturated fatty acid biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →