Regulation of unsaturated fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5, CHMP4B, and L1CAM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of unsaturated fatty acid biosynthetic process activity versus FABP5 in SOFT_TISSUE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FABP5 →	+4.676	+2.428	.008	<.001	3	9
LARGE_INTESTINE	CHMP4B →	-0.840	-1.235	<.001	<.001	3	6
LUNG_NSCLC_LUSC	L1CAM →	-6.126	-1.895	.003	<.001	2	6
OVARY	HM13 →	-1.479	-1.630	.005	.001	3	5
OVARY	SLC44A2 →	-2.302	-1.452	.001	<.001	3	5
OVARY	THEMIS2 →	-2.230	-1.277	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001279 vs FABP5 — SOFT_TISSUE

Explore this scatter interactively →