Positive regulation of cation channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of cation channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK1, CAMK1, and EPB41L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cation channel activity activity versus HK1 in LSCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HK1 →	+0.369	+0.031	.004	<.001	3	5
OV	CAMK1 →	+0.382	+0.034	<.001	<.001	3	5
UCEC	EPB41L2 →	+0.582	+0.051	.001	<.001	3	5
GBM	TBL3 →	-0.185	-0.047	<.001	<.001	3	5
COAD	PRPF4B_S431 →	-0.479	-0.014	.009	.003	3	5
HNSC	BAG3 →	+0.346	+0.057	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001259 vs HK1 — LSCC

Explore this scatter interactively →