Positive regulation of cation channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of cation channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS8, PLAC9, and SNORD12C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cation channel activity activity versus ADAMTS8 in LUAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAMTS8 →	+0.654	+0.578	.008	.002	3	5
BRCA	PLAC9 →	+0.905	+0.614	<.001	<.001	3	5
LSCC	SNORD12C →	-0.458	-0.575	.002	.001	3	5
LSCC	ESPL1 →	-0.718	-0.520	.001	.008	3	5
BRCA	ABCA8 →	+0.886	+0.668	.001	<.001	2	6
LSCC	NPM1P8 →	+0.460	+0.685	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001259 vs ADAMTS8 — LUAD

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