Positive regulation of cation channel activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of cation channel activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, SNRPA, and LMNA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cation channel activity activity versus STIM1 in OVARY (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	STIM1 →	+1.037	+0.231	<.001	.004	2	8
OVARY	SNRPA →	-0.807	-0.329	.002	.005	3	6
BLOOD_Lymphoma	LMNA →	+2.096	+0.661	.005	.006	3	6
OVARY	PTTG1IP →	+1.367	+0.312	.001	.002	2	6
CNS	GAS6 →	+2.250	+0.178	<.001	.002	3	5
OVARY	UQCRH →	-3.974	-0.278	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001259 vs STIM1 — OVARY

Explore this scatter interactively →