Negative regulation of chromosome organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of chromosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFATC2, ZNF862, and TMPO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFATC2 grouped by Negative regulation of chromosome organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NFATC2 →	-1.400	-0.163	.006	.003	3	5
BLOOD_Lymphoma	ZNF862 →	+1.025	+0.265	.002	.008	3	4
CNS	TMPO →	-0.412	-0.157	.008	.007	2	5
KIDNEY	NAE1 →	-0.604	-0.229	.009	.005	3	4
KIDNEY	TANC2 →	+1.834	+0.211	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PLPP1 →	+1.211	+0.135	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFATC2 by Negative regulation of chromosome organization activity — BLOOD_Leukemia

Explore this box plot interactively →