Negative regulation of intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRRS1L, IL4I1, and THEMIS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway activity versus FRRS1L in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FRRS1L →	-1.025	-0.206	.001	<.001	3	5
BRCA	IL4I1 →	+1.017	+0.189	.003	.001	2	6
BRCA	THEMIS2 →	+0.582	+0.116	<.001	.002	3	5
BRCA	GPR84 →	+0.510	+0.170	.007	.004	3	5
GBM	ITGB2 →	+1.085	+0.180	<.001	<.001	3	5
GBM	SERPINE1 →	+1.580	+0.155	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001243 vs FRRS1L — GBM

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