Regulation of intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARF, DEGS1, and SOD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway activity versus CARF in BRCA (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CARF →	-0.886	-0.301	.005	.004	3	2
BRCA	DEGS1 →	+1.089	+0.364	.005	.001	3	2
COAD	SOD2 →	+0.824	+0.100	<.001	<.001	3	2
OV	TENT5A →	+0.619	+0.148	.004	.004	3	2
COAD	KIF20A →	+0.433	+0.104	.002	<.001	3	2
COAD	MASTL →	+0.528	+0.134	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001242 vs CARF — BRCA

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