Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA patient cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NF1, RPL23AP82, and MIR193BHG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand activity versus NF1 in GBM (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NF1 →	+0.658	+0.202	<.001	.003	3	4
LSCC	RPL23AP82 →	+0.358	+0.155	.009	.009	3	4
LUAD	MIR193BHG →	+0.421	+0.142	<.001	<.001	3	4
UCEC	GZMA →	-1.281	-0.209	<.001	<.001	3	3
UCEC	FBXL2 →	+0.579	+0.169	.001	.003	3	3
HNSC	SOCS5 →	+0.771	+0.173	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001241 vs NF1 — GBM

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