Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA cell cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF331, LPIN3, and SLAMF9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF331 grouped by Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF331 →	+1.097	+0.231	.002	<.001	3	3
BLOOD_Myeloma	LPIN3 →	+1.944	+0.338	<.001	.003	3	2
CNS	SLAMF9 →	-0.382	-0.608	.003	.006	3	2
LUNG_SCLC	RABGEF1 →	-0.575	-0.273	.004	.009	3	2
LUNG_SCLC	HDAC3 →	+0.506	+0.212	.003	<.001	3	2
LUNG_SCLC	BTBD9 →	+0.935	+0.264	.001	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF331 by Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand activity — LUNG_SCLC

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